Proteomic characterization of the murine cardiac proteasome complexes

【Author】

Peipei Ping Departments of Physiology, Medicine and Division of Cardiology, Division of Molecular Medicine; UCLA School of Medicine. Los Angeles CA 90075, USA

【Abstract】

<正>We have developed a general strategy for organelle-based proteomics in the heart. This approach includes the isolation of organelles, validation of purified organelles, LC/MS/MS based protein identification of molecular components of the organelles and characterization of their posttranslational modifications, and finally functional validation of identified proteins. Using this technology platform we have successfully conducted studies to characterize organelles in the cardiac myocytes;an example of cardiac proteasomes is given here. Specifically,

【Keywords】

this;MS;LC;Proteomic characterization of the murine cardiac proteasome complexes;

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