Functional proteomics of chloride channels in the heart

【Author】

Maggie Huang;Fiona C.Britton;Sunny Xiang;Kathleen Schegg;William J.Hatton;Gregory Pari;

【Abstract】

<正>Chloride (Cl-) channels are important in cardiac function in the context of health and disease. At the molecular level, at least four distinct genes, namely the cystic fibrosis transmembrane-conductance regulator (CFTR), the CIC, the CLCA, and bestrophin, have been found to be responsible for various endogenous Cl- channels in mammalian heart. Similar to many cationic channels, Cl- channels are often regulated at multiple levels, including posttranslational modification and differential assembly of homo- or heterologqus membrane-embedded pore-forming subunits and the soluble cytoplasmic regulatory subunits.

【Keywords】

CIC;Functional proteomics of chloride channels in the heart;

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