Cardiac Na+/Ca2+ exchange system was regulated under physiological and pathophysiological conditions

【Author】

Xiaolianq Wang,Hongyi Zhou, Chongyang Han, Ling Wang & Shaofeng Xiu Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College

【Abstract】

<正>Na+-Ca2+ exchange (NCX) is a major pathway for remove of cytosolic Ca2+ in cardiac myocytes. We investigated the regulation of NCX under physiological condition and under the condition of cardiac hypertrophy and heart failure. It was found that at 34℃ the INa/Ca was 4 fold higher than it at 22℃. Intracellular ATP depletion and acidification at 22℃ did not markedly affect INa/Ca.

【Keywords】

Na;NCX;than;ATP;Cardiac Na;exchange system was regulated under physiological and pathophysiological conditions;mode;

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