Pivotal role of chplinergic nerves in the electrical field stimulation-induced corpus cavernosum relaxation isolated from nNOS null mice

【Author】

C.E.Teixeira;R.C.Webb;

【Abstract】

<正>OBJECTIVE: Despite the overwhelming evidence illustrating the involvement of the nitric oxide (NO)/cGMP pathway in the control of penile erection, little is known about the contribution of specific NOS isoforms to erectile function. Mice with a null mutation of the nNOS gene are devoid of nNOS expression, yet possess erectile function sufficient for copulation and reproduction. In addition, mice lacking the eNOS isoform are capable of adequate reproductive function. In this study, we examined mice with targeted deletions of either nNOS or eNOS to understand the contribution of each isoform to erectile function in the absence and presence of electrical field stimulation (EFS) of the intrinsic nerves.

【Keywords】

nNOS;Pivotal role of cholinergic nerves in the electrical field stimulation-induced corpus cavernosum relaxation isolated from nNOS null mice;

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