Superoxide generation from nitric oxide synthases


Yong Xia Davis Heart and Lung Research Institute, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA


<正>Nitric oxide (NO), a gaseous free radical, is a fundamental signaling molecule and effector in a variety of physiological and pathological processes. In cells, NO is produced by a family of NO synthase (NOS) including neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). In addition to NO, NOS also produces superoxide, a primary reactive oxygen species. Superoxide generation was first found with nNOS. Subsequent studies revealed superoxide


NOS;Superoxide generation from nitric oxide synthases;


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