NAD(P)H oxidase-derived hydrogen peroxide as a key signalling molecule in vascular pathophysiology

【Author】

Hua "Linda" Cai;

【Abstract】

<正>Reactive oxygen species (ROS) are produced in all aerobic cells and traditionally considered toxic by-products of the respiration chain. Data accumulated in the past decade however have shown that production and degradation of ROS in vascular endothelial cells and smooth muscle are tightly controlled by complex enzymatic pathways. Some ROS such as superoxide (O2(?)-) and hydrogen peroxide (H2O2), play important roles in vascular growth signalling physiologically, or at higher concentrations.mediate development and progression of vascular diseases.We

【Keywords】

eNOS;NAD;P)H oxidase-derived hydrogen peroxide as a key signalling molecule in vascular pathophysiology;DHFR;

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