Richard Cohen;
<正>Although a role of oxidative stress in various cardiovascular diseases has been widely reported, the vascular location and the role of various oxidase have been controversial. NADPH oxidase is one of the major superoxide anion generating systems. The enzyme subunits are expressed in all cell types in vascular wall. Our group has shown that the adventitia is also an important site of suoeroxide anion production in normal rat aorta and NADPH oxidase subunits are found in
Role of adventitia in vascular oxidative stress;
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