Role of nitric oxide in vascular protective effect of recombinant erythropoietin

【Author】

Livius V.d'Uscio;Zvonimir S.Katusic;

【Abstract】

<正>Erythropoietin (EPO) is a hypoxia-inducible hormone that is essential for normal erythropoiesis in bone marrow. Administration of recombinant human EPO is an efficient and safe therapeutic approach to anemia associated with chronic renal failure. However, EPO receptors are also widely distributed in the cardiovascular system, including endothelial, smooth muscle, cardiac, and other cell types. More recently, EPO has been recognized as a tissue protective cytokine. Our studies have been designed to test the hypothesis that endothelial nitric oxide synthase

【Keywords】

EPO;Role of nitric oxide in vascular protective effect of recombinant erythropoietin;

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