Development of non-peptide CGRP antagonists

【Author】

Henri Doods;

【Abstract】

<正>It is well established that plasma levels of the potent vasodilator Calcitonin Gene-Related Peptide (CGRP) are elevated in migraine patients during the headache phase. Based on the hypothesis that the release of CGRP could play a causative role in migraine headache we initiated a program aimed at the design of small molecule CGRP receptor antagonists. Optimization of weakly active lead structures led to the identification and development of the first

【Keywords】

CGRP;Development of non-peptide CGRP antagonists;

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