Interaction of α-CGRP andβ-CGRP with the CGRP receptor system of human extracranial arteries




<正>The α- and β-calcitontin gene related peptides (α-CGRP and β-CGRP) are encoded by different genes but mediate similar relaxant vascular effects. There is, however, controversy about the relative potencies and receptor mechanisms involved. We compared the relaxant effects of α- CGRP and β-CGRP, as well as the antagonism of BIBN4096BS and α-CGRP8-37, on rings of human temporal artery and human occipital arteries. α-CGRP and β-CGRP relaxed


Human temporal and occipital arteries; α-CGRP- and β-CGRP-evoked relaxations;BIBN4096BS; CGRP8-37


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