Epoxyeicosatrienoic acids: impact on signal transduction, gene expression and function of vascular cells

【Author】

Rudi Busse;

【Abstract】

<正>Nitric oxide and prostacyclin-independent vasodilatation in several vascular beds has been linked to the activation of cytochrome P450 (CYP) epoxygenases expressed in endothelial cells and the generation of vasodilator epoxyeicosatrienoic acids (EETs). EETs contribute to the activation of small and intermediate Ca2+-dependent K+ channels in endothelial cells and the subsequent hyperpolarization, by a mechanism that involves the opening of TRP channels and

【Keywords】

In;CYP;EET;Epoxyeicosatrienoic acids;

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