Mechanisms and effects of drugs related to the endothelin system

【Author】

Eric Thorin;Stéphanie Sauvageau;Jocelyn Dupuis;

【Abstract】

<正>Since their discovery in 1988 by Yanagisawa's group, endothelins (ET) have been investigated mostly from a pathophysiological perspective. Of the three known isoforms of ET (ET-1, -2 and -3), ET-1 is the most studied. It is one of the most potent vasoconstrictor, promotes cellular proliferation and fibrosis and has been associated with inflammation and oxidative stress. Plasma ET-1 levels are increased in most, if not all, cardiovascular pathologies and this has

【Keywords】

Mechanisms and effects of drugs related to the endothelin system;ETA;

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