Janus-faced roles of endothelial NO synthase in vascular disease: Can pharmacology uphold the favorable side?

【Author】

Ulrich Forstermann;Sven Horke;

【Abstract】

<正>Endothelium-derived nitric oxide (NO) exerts important protective functions in the vasculature. These include prevention of platelet adhesion, reduced expression of chemokines and adhesion molecules and inhibition of smooth muscle proliferation. Endothelial NO synthase (eNOS) is the predominant enzyme responsible for vascular NO synthesis. A functional eNOS transfers

【Keywords】

eNOS;Janus-faced roles of endothelial NO synthase in vascular disease;NADPH;

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