Adventitial control of vascular tone


Chao-Yu Miao Department of Pharmacology, Second Military Medical University, Shanghai, China


<正>The adventitia may have layer-specific roles in the regulation of arterial tone. The adventitial compacta enhances vasoconstriction and impairs endothelium-dependent vasodilatation, mainly due to fibroblast-derived superoxide and neurotransmitter. However, the adventitial fat inhibits vascular contraction and produce vascular relaxation, which is explained by the release of adventitium- or adipocyte-derived relaxing factor (ADRF).


Adventitial control of vascular tone;


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