Mobilizing a-adrenoceptors:a novel mechanism for regulating vascular neuroeffector function

【Author】

MA Chotani;S Mitra;AH Eid;NA Flavahan;

【Abstract】

<正>Heptahelical α-adrenoceptors (α-ARs) are members of the G-protein-coupled receptor (GPCR) superfamily and mediate vascular responses to norepinephrine and epinephrine. Efficient activation and signaling of α-ARs requires that the receptors be correctly localized within the plasma membrane. However, for certain subtypes of α1-ARs and α2-ARs, the receptors are sequestered within intracellular compartments. The directed mobilization of these receptor

【Keywords】

adrenoceptors;AR;CMP;Mobilizing;

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