Raloxifene modulation of endothelial function


Yu Huang Department of Physiology, Chinese University of Hong Kong, Hong Kong, China


<正>Because of their tissue-specific estrogen-agonist/antagonist properties, selective estrogen receptor modulators (SERMs) may be beneficial to the cardiovascular system and bone without causing much of undesirable side effects of hormonal therapy. However, the vascular actions of SERMs such as raloxifene are incompletely understood. Hypercholesterolemia, oxidative stress and atherosclerosis are closely associated with unfavorable alterations in vascular reactivity,




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