Harnessing PDE5 and NOS:New approaches to limiting cardiac hypertrophy/remodeling


David Kass;Eiki Takimoto;Diego Belardi;An Moens;Hunter Champion;


<正>Sustained pressure loading results in cardiac remodeling, initially triggering concentric hypertrophy with preserved systolic and diastolic function, but can lead to chamber dilation, worsened hypertrophy, depressed function and frank cardiac failure. Many molecular pathways contribute to both phases of this process. Our laboratory has focused on the role of cyclic GMP catabolism and its primary generator enzyme nitric oxide synthase to this process. PDE5a, a


NOS;PDE;Harnessing PDE5 and NOS;


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