Proto-oncogene c-myc, a therapeutic target for cardiac hypertrophy

【Author】

Mahajou Bello Roufai;

【Abstract】

<正>Background: The protooncogene c-myc is involved in the regulation of cell growth. Although increased c-Myc expression is found in hypertrophied hearts, the role of c-Myc in the development of cardiac hypertrophy has never been determined. The aim of this study was to test the effect of heart-specific inhibition of c-Myc expression on the development of cold-induced cardiac hypertrophy (CICH), a natural form of cardiac hypertrophy. We hypothesized that heart-specific inhibition of c-Myc expression attenuates CICH.

【Keywords】

GFP;Proto-oncogene c-myc;a therapeutic target for cardiac hypertrophy;

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