Crucial roles of Akt on cytoprotection against delayed cell death following heart and brain ischemia

【Author】

Kohji Fukunaga;Md.Shenuarin Bhuiyan;Norifumi Shioda;

【Abstract】

<正>Phosphatidylinositol-3-kinase (PI3K)/Akt pathway has central role in the cell survival. We recently documented that ischemia-induced decrease in Akt activity mediates delayed cell death both in heart and brain ischemia/reperfusion models (1-3). However, the downstream targets underlying cell death after Akt inactivation have not been defined. We here documented precise spatial and temporal profiles of Akt inactivation with concomitant dephosphorylation of forkhead

【Keywords】

Akt;Crucial roles of Akt on cytoprotection against delayed cell death following heart and brain ischemia;cell;

References

To explore the background and basis of the node document

Springer Journals Database

Total: 3 articles

  • [1] Kawano et al, J. Cereb. Blood Flow & Metab,
  • [2] Hasegawa et al, J. Cereb. Blood Flow & Metab,
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