Dexamethasone modulates neuronal nitric oxide release through protein kinase C in mesenteric arteries from spontaneously hypertensive rats

【Author】

G.Balfagón;R.Aras-López;J.Blanco-Rivero;M.Ferrer;

【Abstract】

<正>Perivascular nitrergic innervation in superior mesenteric arteries releases neuronal nitric oxide (NO) under electric stimulation and participates in vascular tone regulation in spontaneously hypertensive rats (SHR) but not Wistar-Wyoto (WKY). This neuronal NO is synthesized by neuronal NO synthase (nNOS), which is positively modulated by protein kinase C (PKC). Many studies have reported that glucocorticoids inhibit NO production in the central nervous system and endothelial cells. The aim of this study was to assess the effect of dexamethasone (DEX) on

【Keywords】

DEX;PKC;Dexamethasone modulates neuronal nitric oxide release through protein kinase C in mesenteric arteries from spontaneously hypertensive rats;EFS;

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