Role of α_2-adrenoreceptor in the expression of endothelium-derived CGRP in phenol-induced hypertensive rats

【Author】

Hui-Dan Zhang,Feng Ye, Dan Luo, Yi-Wei Zhang, Han-Wu Deng & Yuan-Jian Li Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 10078, China

【Abstract】

<正>Objective: To investigate the role of α2-adrenoreceptor in the expression of endothelium-derived CGRP in phenol-induced hypertensive rats. Methods: Neurogenic hypertensive rats were induced by injection of phenol in the left kidney. The expression of CGRP mRNA and content of CGRP in the artery endothelium were measured by in situ hybridization

【Keywords】

Endothelial cells; Calcitonin gene-related peptide; Hypertension; α2-adrenoreceptor

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