Effects of intravenous urocortin on angiotensin-converting enzyme in rats


Cui Yang,Yuqing Wu,Yinyan Xu & Shengnan Li Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China


<正>We investigated the relationship between urocortin and the activity of angiotensin converting enzyme (ACE). The tissue ACE mRNA was determined by RT-PCR. Immunofluorescence studies were preformed to evaluate the effect of urocortin on ACE in cultured rat aortic endothelial cells (RAECs). Urocortin decreased the serum ACE level 1h after administration, whereas tissue ACE immunoreactivity and mRNA did not change. The prolonged administration


Urocortin; ACE; Blood pressure


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