Role of calcium desensitization in vascular hyporeactivity following hemorrhagic shock and the restitution effect of vasopressin

【Author】

L.M. Liu,J. Xu, G.M. Yang, T. Li, J. Ming & D.Y. Hu State Key Laboratory of Trauma, Burns and Combined Injury, The 2nd Department of Research Institute of Surgery, Daping Hospital, The Third Military University, Chongqing 400042, P.R.China

【Abstract】

<正>After severe trauma or shock, vascular reactivity to vasoconstrictors and vasodilators is greatly reduced. Our previous study showed that calcium overload and calcium desensitization (the decrease of force/Ca2+ ratio) coexisted in the myocardium cell following severe trauma or shock. Calcium overload was also found in VSMC following shock. But whether calcium desensitization exists in the vascular smooth muscle cell (VSMC) and plays important roles in vascular hyporeactivity following hemorrhagic shock are still unknown. To elucidate this problem and get

【Keywords】

Hemorrhagic shock, Vascular reactivity, Calcium sensitivity, Arginine vasopressin

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