Intercellular calcium signaling and nitric oxide feedback during constriction of rabbit renal arterioles

【Author】

Jeppe Schjerning;Torben R Uhrenholt;Paul M Vanhoutte;Boye L Jensen;Ole Sk■tt;

【Abstract】

<正>The increase in intracellular calcium concentration ([Ca2+]i) in vascular smooth muscle cells (VSMC) which is associated with vasoconstriction may increase endothelial cell (EC) [Ca2+]i. This may stimulate the endotheliai nitric oxide synthase, release nitric oxide (NO) and counteract the vasoconstriction. We tested this hypothesis in microperfused rabbit afferent

【Keywords】

endothelium, calcium wave, nitric oxide, smooth muscle

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