Role of cyclic GMP-dependent protein kinase in the development of tolerance to nitroglycerin of porcine coronary arteries

【Author】

Dou Dou,Xiaoxu Zheng & Yuansheng Gao Dept.of Physiology & Pathophysiology, Peking University Health Science Center, Beijing, 100083, China

【Abstract】

<正>Objective: Cyclic GMP-dependent protein kinase (PKG) is an important mediator for the actions of nitrovasodilators such as nitroglycerin and nitric oxide. The present study was to determine the role of PKG in the development of tolerance to vasodilation induced by nitroglycerin. Methods: Isolated porcine left anterior defending and left circumflex coronary arteries were were dissected from the heart and cut into rings (outside diameter: -3.1 mm; length:-5mm) in

【Keywords】

PKG;Role of cyclic GMP-dependent protein kinase in the development of tolerance to nitroglycerin of porcine coronary arteries;GMP;

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