The nicotinic α7 receptor pathway is involved in the antishock effects of anisodamine

【Author】

Chong Liu, Ya-jun Zhang & Ding-Feng Su Department of Pharmacology, Second Military Medical University, Shnaghai 200433, China

【Abstract】

<正>Anisodamine, an anticholinergic drug, is widely used in China for treatment of acute circulatory shock but mechanisms of its action are not fully known. In this study we aimed to investigate whether the therapeutic efficacy of anisodamine in the treatment of endotoxic shock could--at least in part-be brought about by its activation of the cholinergic anti-inflammatory pathway. Thus,we investigated the effect of methyllycaconitine (MLA), a nicptinic acetylcholine receptor (nAChR) α7 subunit antagonist, on antishock action of anisodamine in LPS-induced shock.

【Keywords】

MLA;TNF;In;receptor pathway is involved in the antishock effects of anisodamine;The nicotinic;

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