Caloric restriction increases stroke-prone spontaneously hypertensive rats' lifespan, involved SIRT1 and arterial baroreflex function


Ai-jun Liu & Ding-feng Su Department of pharmacology, Pharmacy College, Second Military Medical University, China


<正>Background and purposes: Caloric restriction (CR) has been shown to increase life span in rodents and other species. The goal of the study was to investigate the effect of CR on the lifespan of male stroke-prone spontaneously hypertensive rats (SHR-SP) and its mechanism. Methods: One hundred SHR-SPs, in the age of 12 weeks, were fed ad libitum (AL) or CR diet (60% of AL). Survival time was observed in 67 rats. After 24 weeks of CR, other 20 rats were


Caloric Restriction, SIRT1, Arterial baroreflex, Barorelex sensitivity, Apoptosis,Sinoaortic denervated


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