The biphasic effect of haloperidol on sodium current of ventricular myocytes of guinea pig

【Author】

Parhat Kerram;

【Abstract】

<正>Aim: To study the effects of Haloperidol on sodium current (/Na) of ventricular myocytes in guinea pigs. Method: Individual ventricular myocytes were isolated with enzymatical dissociation method and whole-cell patch clamp technique was used to observe the effects of Haloperidol on sodium current of ventricular myocytes. Results: Haloperidol (0.1-3 μmol·L-1) inhibited /Na in a concentration-dependent manner with an IC50 of 0.253 ?0.015 μmol·L-1.Inhibition rate of

【Keywords】

The biphasic effect of haloperidol on sodium current of ventricular myocytes of guinea pig;

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