Remodeling of transient outward potassium channel in left ventricle of rabbits with heart failure and intervention with losartan and simvastain

【Author】

Jifeng Yan & Zhihua Liu Department of Cardiology, The First Affiliated Hospital Soochow University, China

【Abstract】

<正>Objective: To investigate remodeling of transient outward potassium channels in left ventricle(LV) of rabbits with heart failure (HF) and intervention with type 1 angiotensin n acceptor antagonists and statins. Methods: Rabbits models of HF were established by ligating the left anterior descending coronary artery.Sham group (Group A,n=12). HF group (Group B,n=11), Treatment group with losartan (Group C,n=13, 10 mg.kg.-1.d-1 started 10 weeks from the third day after operation. Treatment group with simvastain (Group D,n=10, 10 mg.kg.-1.d-1

【Keywords】

left;Remodeling of transient outward potassium channel in left ventricle of rabbits with heart failure and intervention with losartan and simvastain;

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