Cellular basis of abnormal calcium cycling of failing rabbit myocytes and effects of metoprolol and losartan

【Author】

Cao Zou & Zhi-hua Liu Department of Cardiology, The first Affiliated Hospital Soochow University,Suzhou, China

【Abstract】

<正>Objective: In this study,we established animal model of heart failure induced by volume plus pressure overload in rabbits in order to investigate cellular basis of abnormal calcium cycling of failing myocytes.Then we observed th e effects of Metoprolol and Losartan on th e failing hearts to understand its molecule mechanism deeply

【Keywords】

Heart failure;Calcium cycling;Calcium regulatory protein;L-type calcium channel(LTCC);Calcium release channel(Ryr2);SERCA2a;Na~+-Ca~(2+) exchanger(NCX);Metoprolol;Losartan

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