Neuroprotective action of prostaglandin A_1 and its mechanisms involving NF-κB inhibition and PPARγ activation in rat models of focal cerebral ischemia


Hui-Ling Zhang,Zhen-lun Gu & Zheng-Hong Qin Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China


<正>Aim: To investigate the neuroprotective effects of prostaglandin A1( PGA1) and the relationships between its neuroprotection and inhibition of IKK/IκB/NF-KB/c-Myc signaling pathway, and activation of PPARyin rat models of permanent focal cerebral ischemia. Methods: Permanent middle cerebral artery occlusion (pMCAO) model was induced by using intraluminal filament technique in rats. PGA1 was injected intracerebroventricularly (icv) immediately after the onset of


prostaglandin A1; cerebral ischemia; neuroprotection; apoptosis; NF-κB; PPAR γ;signal transduction


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