Puerarin reduces increased c-fos,c-jun and type IV collagen expression caused by high glucose in glomerular mesangial cells

【Author】

Cai-ping Mao & Zhen-lun Gu Department of Pharmacology, Suzhou Institute of Chinese Materia Medica, Medical College of Soochow University, Suzhou 215007, Jiang Su, China

【Abstract】

<正>Aim: Increased expression of c-fos, c-jun and type Ⅳ collagen (ColV) in glomerular mesangial cells (GMC) are important characteristics of diabetic nephropathy. Both c-fos and c-jun regulate the gene expression of extracellular matrix components, and ColV is the main component of the extracellular matrix. It has been reported that puerarin inhibits aggregation of the extracellular

【Keywords】

puerarin; glomerular mesangial cells; extracellular matrix; diabetic nephropathy

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