Dlhydromyricetin prevents AngⅡ-induced rat cardiomyocyte hypertrophy through NO-depentment pathway


Guo-liang MENG;Yun CHEN;Wei ZHANG;


<正>Aim:Dihydromyricetin displays a range of biological properties.The aim of study was to investigate whether dihydromyricetin had the potential therapeutic value to protect angiotensinⅡ-induced cardiomyocyte hypertrophy of rat.Methods: Degree of hypertrophy was evaluated by cell surface analysis.Expression of ANP andβ-MHC mRNA was measured with real-time PCR.Production of NO in myocardial cells was assessed using the NO-specific fluorescent dye 3-amino,4- aminomethyl-2,7-difluorescein,diacetate(DAF-FM DA).Results:Pre-incubation


dihydromyricetin;;NO;;cardiomyocyte hypertrophy


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