Dihydrotanshinone I inhibits LPS induced LOX-1 expression via TLR4/ROS/NF-κB signal pathway in human umbilical vein endothelial cells

【Author】

Wen-wen ZHAO;Gui-xin MA;Xiu-ping CHEN;

【Abstract】

<正>Aim:Lectin-like receptor for oxidized low density lipoprotein(LOX-1) has been implicated as the main receptor for oxidized low density lipoprotein(oxLDL) primarily expressed in endothelial cells.and it allows uptake of ox-LDL into endothelial cells.It is considered as a potential target for atherosclerosis. Dihydrotanshinone I(DT) is one of the major active components isolated from Chinese herb Salvia miltiorrhiza.In the present study,the effect of DT on LPS induced LOX-1 expression in human umbilical vein endothelial cells(HUVECs) and the possible molecular pathways were investigated.Methods:The cytotoxicity

【Keywords】

dihydrotanshinone 1;;LOX-1;;ROS;;endothelial cells

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