Effects of traditional Chinese medicine bruclne on alcohol consumption and preference in alcohol-preferring FH/Wjd rats

【Author】

Yu-ling LI;Jian-hui LIANG;

【Abstract】

<正>Aim:To evaluate pharmacological and toxicological effects on alcoholism of brucine(BRU),isolated from traditional Chinese medicine Strychnos nux-vomica. Methods:FH/VVjd rats were used to study the roles of BRU on alcohol,sucrose intake and their preference in two-bottle choice test.In the paradigm of 5-d alcohol deprivation,antagonism of BRU on alcohol craving was investigated.Besides,the effects of BRU on locomotion,feeding and body weights were measured.To test the abuse potential of BRU,Conditioned Place Preference(CPP) was performed.

【Keywords】

brucine;;alcoholism;;FH/Wjd rat

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