The Absence of Dystrophin Rather Than Muscle Degeneration Causes Acetylcholine Receptor Cluster Defects in Dystrophic Muscle

【Author】

jie Kong;liqing Yang;qiuling Li;jiqing Cao;juan Yang;fei Chen;yanyun Wang;cheng Zhang;

【Abstract】

<正>Objective To explore whether the disruption of AChR distribution in mdx mice is due to lack of dystrophin or whether it is downstream of muscle degeneration. Method AChR clusters and muscle degeneration were compared between mdx mice(mutated dystrophin) and dko mice(mutated dystrophin and utrophin).AChR clusters were identified by

【Keywords】

AChR;The Absence of Dystrophin Rather Than Muscle Degeneration Causes Acetylcholine Receptor Cluster Defects in Dystrophic Muscle;

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