Broad and largely concordant molecular changes unexpectedly mark tolerogenic and immunogenic dendritic cell maturation in thymus and periphery

【Author】

Bernard Malissen;

【Abstract】

<正>Dendritic cells(DCs)are instrumental in the initiation of T cell responses but how thymic and peripheral tolerogenic DCs differ globally from Toll-like receptor(TLR)-induced immunogenic DCs remains unclear.We will present data showing that thymic XCR1+DCs undergo a high rate of maturation,accompanied by profound gene-expression changes that are essential for central tolerance and also happen in

【Keywords】

maturation;instrumental;thymus;happen;periphery;accompanied;largely;globally;profound;unclear;

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