The cGAS pathway of cytosolic DNA sensing and its role in health and disease


Zhijian James Chen;


<正>In animal cells,DNA is normally present in the nucleus and mitochondria.When microbes infect cells,the presence of microbial DNA in the cytoplasm is perceived by the host as a danger signal that triggers defensive immune responses.We have recently identified cyclic GMP-AMP synthase(c GAS)as the sensor of cytosolic DNA that triggers the type-I interferon(IFN)pathway and other innate immune responses.




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