Detection of dead cells and pathogens by dendritic cells

【Author】

Caetano Reis e Sousa;

【Abstract】

<正>Direct sensing of pathogen components is a major trigger of dendritic cell(DC)activation,leading to innate and adaptive immunity.Over the years,we have studied multiple pattern-recognition pathways that mediate DC activation.One pathway for sensing infection by RNA viruses involves recognition of viral genomes or virally-infected cells in endosomal compartments and utilises members of the toll-like

【Keywords】

immunity;innate;pathogen;infected;trigger;RNA;presentation;committed;subtype;picture;

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