Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis

【Author】

Mark Chong;

【Abstract】

<正>Micro RNAs(mi RNAs)are small inhibitory RNAs that regulate the translation of m RNAs.To investigate if this pathway is required for the dendritic cell(DC)development,we investigated the impact of ablating the RNase III enzymes Drosha and Dicer within the hematopoietic system of bone marrow chimeric mice.These enzymes are central to mi RNA biogenesis.We found that DC development(and the

【Keywords】

encoding;hematopoietic;Dicer;messenger;regulate;populations;enzymes;RNase;RNA;myeloid;

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