Novel Insights into human SLE pathogenesis

【Author】

Virginia Pascual;

【Abstract】

<正>Systemic Lupus Erythematosus(SLE)is a systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and the development of DNA and RNA-containing immune complexes(IC).Genomic approaches have shown that>95%of children with SLE display unique blood signatures,that include type I IFN-plasma cell-and neutrophil-related transcripts.A connection between these signatures seems to exist,as activation of SLE neutrophils with TLR7-agonistic

【Keywords】

autoimmune;pathogenesis;Lupus;transcripts;neutrophil;breakdown;Genomic;complexes;children;DNA;

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