“Plasmacytoidopathy”: from systemic autoimmunity to metabolic syndrome

【Author】

Dipyaman Ganguly;

【Abstract】

<正>Plasmacytoid dendritic cells(p DC)are major producers of type I interferons(IFN-I)in response to recognition of pathogen-derived nucleic acid molecules by endosomal toll-like receptors.Involvement of p DC-derived IFN-I in a number of autoimmune diseases as well is established.Recognition of self nucleic acids leads to induction of IFN-I from p DCs and drives innate initiation of inflammation in Systemic Lupus

【Keywords】

autoimmune;Lupus;Recognition;innate;nucleic;inflammation;pathogen;induction;initiation;enable;

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