The transcriptional regulators Polycomb group factor 6(PCGF6) and JARID1c negatively regulate dendritic cell activation and promote quiescence

【Author】

Giselle Boukhaled;Brendan Cordeiro;Genevieve Deblois;Vassil Dimitrov;Swneke Bailey;Thomas Holowka;Anisa Domi;Hannah Guak;Huai-Hsuan Clare Chiu;Bart Everts;Edward Pearce;Mathieu Lupien;John White;Connie Krawczyk;

【Abstract】

<正>Pro-inflammatory signals provided by the microenvironment are critical to activate Dendritic Cells(DCs),critical components of the innate immune system that shape both innate and adaptive immunity.However,to prevent inappropriate immune activation,mechanisms must be in place to restrain DC activation and maintain quiescence to ensure DCs are activated only once sufficient stimuli have been

【Keywords】

innate;inappropriate;restrain;immunity;maintain;activate;regulate;negatively;stimuli;stimulation;

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