Interferon lambda and dendritic cells

【Author】

Christophe Macri;Ee Shan Pang;Joanne Pooley;Ben Fancke;Hubertus Hochrein;Kristen Radford;Meredith OKeeffe;

【Abstract】

<正>Interferon lambda(IFN-λ)is a recently identified cytokine that is secreted by dendritic cells(DC).Despite its binding to a different receptor(IFN-λR),IFN-λshares functional similarities with type I IFN(IFN-I)by activating a STAT-dependent signalling pathway that leads to the upregulation of interferon-stimulated genes.As with IFN-I,plasmacytoid DC are a major source of IFN-λin response to Toll-Like

【Keywords】

Interferon;activating;interferon;cytokine;shares;stimulated;secreted;downstream;autoimmune;erythematosus;

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