Differential roles for IKKalpha and IKKbeta in DC activation: implications in immunity and tolerance

【Author】

Toby Lawrence;

【Abstract】

<正>NF-kappa B is the prototypical pro-inflammatory transcription factor and often used as a marker for dendritic cell(DC)activation.NF-kappa B activation downstream of Toll like receptor(TLR)signaling or pro-inflammatory cytokines such as TNFalpha and IL-1beta,is regulated by the Ikappa B kinase(IKK)complex.The IKK complex consists of two serine/threonine kinases(IKKalpha and IKKbeta)and the

【Keywords】

immunity;downstream;threonine;signaling;cytokines;serine;marker;maturation;ubiquitin;upstream;

References

To explore the background and basis of the node document

Springer Journals Database

Total: 0 articles

Similar documents

Documents that have the similar content to the node document

Springer Journals Database

Total: 60 articles

More>>