MyD88 signaling contributes to TLR-driven metabolic reprogramming in dendritic cells

【Author】

Lucia Minarrieta;Peyman Ghorbani;Maxine Swallow;Wolf-Rainer Abraham;Tim Sparwasser;Luciana Berod;

【Abstract】

<正>Introduction Dendritic cells(DCs)undergo a metabolic shift upon TLR-induced activation,characterized by an increase in glycolysis,which fuels de novo fatty acid synthesis(FAS)through the generation of biosynthetic precursors via the Tricarboxylic Acid(TCA)cycle.Evidence suggests that newly synthesized fatty acids are required during DC activation to sustain the development of new ER and Golgi membrane that carry

【Keywords】

sustain;cycle;signaling;fuels;carry;cytometry;assessed;maturation;phospholipid;accompanied;

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