BAD-LAMP controls TLR9 endosomal trafficking and signaling in human plasmacytoid dendritic cells

【Author】

Alexis Combes;Philippe Pierre;Evelina Gatti;

【Abstract】

<正>Human Plasmacytoid dendritic cells(p DCs)have been shown to be the principal producer of type-I interferons(IFNs)following intracellular TLRs stimulation.One major aspect of p DCs activation is the exclusive expression of TLR7 and TLR9 and the tight control of TLRs sub-cellular localization in different endosomes leading to two sequential waves of cytokines production and the.First,early signalling from

【Keywords】

producer;sequential;tight;stimulation;localization;intracellular;TLRs;signaling;cytokines;exclusive;

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