Human Langerhans-type dendritic cells electroporated with murine TRP-2 mRNA stimulate tumor Ag-specific immunity: Results of a phase I vaccine trial in melanoma

【Author】

David J.Chung;Sneh Sharma;Katherine B.Pronschinske;Justin A.Shyer;Shahnaz Singh-Kandah;Richard D.Carvajal;Michael A.Postow;Glenn Heller;Jedd D.Wolchok;James W.Young;

【Abstract】

<正>Purpose:We conducted a phase I vaccine trial to determine safety,toxicity,and immunogenicity of autologous Langerhans-type dendritic cells(LCs)electroporated with murine tyrosinase-related peptide-2(m TRP2)m RNA in patients with AJCC stage IIB,IIC,III,or IV(MIa)melanoma.Experimental Design:Each of nine patients received a priming immunization plus

【Keywords】

Langerhans;melanoma;vaccine;immunity;tyrosinase;stimulate;murine;toxicity;vaccination;autologous;

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