DC-mediated life-long immunity of poliovirus vector-based oral CTL vaccine

【Author】

Jung Hyub Hong;Ezra Lee;Yong-Soo Bae;

【Abstract】

<正>Oral polio vaccine(OPV),a live attenuated polio vaccine is one of the mostsuccessful vaccine programs in human history.OPV comprises 3 different serotypes of attenuated poliovirus Sabin1,Sabin2 and Sabin3.Recently,we have developed and reported an oral CTL vaccine against HIV-1 using a CTP-integrated Sabin1-derived mucosal vaccine vector(RPS-Vax/CTP).Even though OPV-mediated life-long immunity is well known,the detailed mechanism under the life-long

【Keywords】

vaccine;immunity;attenuated;mucosal;programs;vaccination;epithelia;administration;captured;clearance;

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