Type 1 interferons induce changes in core metabolism that are critical for immune function

【Author】

Duojiao Wu;David E Sanin;Bart Everts;Qiongyu Chen;Jing Qiu;Michael Buck;Amber M Smith;Chih-Hao Chang;Zhiping Liu;Maxim N.Artyomov;Erika L.Pearce;Marina Cella;Edward J.Pearce;

【Abstract】

<正>Type 1 interferons(IFNs)induce complex responses that can be beneficial or deleterious,depending on context.Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches.We found that type 1 IFNs induce changes in cellular metabolism that are critical for changes in target cell function.This was apparent in plasmacytoid dendritic cells,which are

【Keywords】

metabolism;apparent;cytokines;specialized;FAO;downstream;oxidative;hematopoietic;diminished;modulate;

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